Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

Completed

• Conditions: Coronary Bypass Graft Surgery; Atrial Fibrillation
• Interventions: Drug: Beta blocker

• Registration Number: NCT03871647
• Lead Sponsor: Ain Shams University

Brief Summary

Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.

Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2019-03-11
• Study First Submitted: 2019-03-11
• Study First Submitted QC: 2019-03-11
• Study First Posted: 2019-03-12
• Primary Completion: 2020-12-07
• Study Completion: 2021-03-07
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-06
• Last Update Posted: 2021-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 256

Inclusion Criteria

1. Age above 18 years.
2. Candidates for CABG surgery without a concurrent valve surgery.
3. Patients receiving perioperative beta blockers before new onset of postoperative AF.

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Exclusion Criteria

1. Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.
2. Serum creatinine >2 mg/dL before the surgery.
3. Uncontrolled thyroid disease.
4. Recent treatment with amiodarone before the occurrence of POAF

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
POAF group	Beta blocker	Patients who will experience AF at any time during the first six days after the operation.
Non POAF group	Beta blocker	Patients with a sinus rhythm during the first six days after the operation.

Primary Outcome Measures

Name	Time	Method
Occurrence of Atrial fibrillation	within 6 days after the operation	Atrial fibrillation based on postoperative electrocardiogram. AF diagnostic criteria will include absence of discrete P waves, the RR intervals follow unrepetitive form and the ranges of ventricular rate usually between 90 and 170 beats/min.

Trial Locations

Locations (1)

The Cardiovascular & Thoracic Academy - Ain Shams University.; 🇪🇬 Cairo, Egypt