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Clinical Trials/NCT00339170
NCT00339170
Completed
Not Applicable

Cognitive Training and Enhanced Supported Employment

Yale University1 site in 1 country98 target enrollmentApril 2000
ConditionsSchizophrenia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Schizophrenia
Sponsor
Yale University
Enrollment
98
Locations
1
Primary Endpoint
Schizophrenia symptoms
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

This study will evaluate the effectiveness of a computer-based cognitive enhancement program plus a work therapy program at improving productivity, work performance, and quality of life in schizophrenic individuals.

Detailed Description

Schizophrenia is a chronic, severe, and disabling brain disorder that affects 2.4 million people in the United States. Individuals with schizophrenia may have difficulties with cognitive functioning, including problems with attention, memory, and organizational thought processes. These factors can lead to decreased productivity and poor work performance, which may make holding a job difficult. Research has shown that certain types of psychological therapies, such as cognitive behavioral therapy, are useful in reducing the severity of schizophrenic symptoms. The purpose of this study is to determine whether a computer-based cognitive enhancement training program, in combination with a work therapy program, will enhance workplace performance, productivity, and quality of life in individuals with schizophrenia. This study will enroll individuals with schizophrenia or schizoaffective disorder. Participants will undergo a cognitive assessment at baseline. They will then be randomly assigned to either a 12-month cognitive enhancement training program plus a 12-month work therapy program or a 12-month work therapy program alone. Participants in the cognitive enhancement training program will receive feedback on their cognitive strengths and weaknesses based on the outcomes of the baseline assessment. The training component will be comprised of 150 computer-based exercises that focus on improving memory, attention, and organizational skills. Participants will attend two weekly meetings: one will focus on providing feedback regarding goal-setting and problem-solving, and the other will focus on improving verbal skills and social information processing. Individuals taking part only in the work therapy program will attend two non-cognitive discussion groups per week. All participants will work up to 20 hours a week in an approved work environment, and will have access to appropriate support services. Following the end of the program, participants will have the option of working an additional 12 months. Schizophrenia symptoms, quality of life, and neuropsychological and rehabilitation effects will be assessed at the end of Years 1 and 2.

Registry
clinicaltrials.gov
Start Date
April 2000
End Date
July 2013
Last Updated
6 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of schizophrenia or schizoaffective disorder

Exclusion Criteria

  • Hospitalized in the 30 days prior to study entry
  • Homeless in the 30 days prior to study entry
  • Changed medications in the 30 days prior to study entry
  • Substance abuse in the 30 days prior to study entry
  • History of head trauma

Outcomes

Primary Outcomes

Schizophrenia symptoms

Time Frame: Measured at Year 2

Vocational functioning

Time Frame: Measured at Year 1

Quality of life

Time Frame: Measured at Year 1

Secondary Outcomes

  • Number of hospitalizations(Measured at Year 2)
  • Income(Measured at Year 2)

Study Sites (1)

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