Cognitive Training and Practice Effects in Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 197
- 试验地点
- 2
- 主要终点
- Auditory Memory Attention Index
研究概览
简要总结
The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment. Practice effects will also be examined as a moderator of treatment response.
详细描述
The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mild Cognitive Impairment, amnestic subtype
- •65 years of age or older
- •Availability of a knowledgeable informant
- •Access to internet 3 hours per week
- •Adequate vision, hearing, and motor responding to participate in training
排除标准
- •History of major stroke, head injury with loss of consciousness of >30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)
- •Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)
- •History of substance abuse
- •Current use of antipsychotics or anticonvulsant medications
- •Currently residing in a nursing home or other skilled nursing facility
结局指标
主要结局
Auditory Memory Attention Index
时间窗: 13 weeks
This is a composite of six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status. It is a standard score (mean=100, standard deviation=15), with a range of approximately 45 - 145, with higher scores indicating better outcome.
次要结局
未报告次要终点
研究者
Kevin Duff
Associate Professor of Neurology
University of Utah