Cognitive Training and Practice Effects in Mild Cognitive Impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: computerized cognitive exercises

• Registration Number: NCT02301546
• Lead Sponsor: University of Utah

Brief Summary

The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment. Practice effects will also be examined as a moderator of treatment response.

Detailed Description

The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-11-21
• Study First Submitted QC: 2014-11-24
• Study First Posted: 2014-11-26
• Study Start: 2015-03
• Primary Completion: 2020-01-28
• Study Completion: 2020-02-28
• Results First Submitted: 2020-04-28
• Status Verified: 2020-05
• Results First Submitted QC: 2020-05-28
• Last Update Submitted: 2020-05-28
• Results First Posted: 2020-06-09
• Last Update Posted: 2020-06-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 197

Inclusion Criteria

• Mild Cognitive Impairment, amnestic subtype

  • 65 years of age or older
  • Availability of a knowledgeable informant

• Access to internet 3 hours per week

• Adequate vision, hearing, and motor responding to participate in training

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Exclusion Criteria

• History of major stroke, head injury with loss of consciousness of >30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)
• Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)
• History of substance abuse
• Current use of antipsychotics or anticonvulsant medications
• Currently residing in a nursing home or other skilled nursing facility

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
experimental cognitive training	computerized cognitive exercises	Participants will use experimental computerized cognitive training exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks.
control cognitive exercises	computerized cognitive exercises	Participants will use control computerized cognitive activities, 1 hour per day, 3 - 5 days per week, for 13 weeks.

Primary Outcome Measures

Name	Time	Method
Auditory Memory Attention Index	13 weeks	This is a composite of six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status. It is a standard score (mean=100, standard deviation=15), with a range of approximately 45 - 145, with higher scores indicating better outcome.

Trial Locations

Locations (1)

University of Utah Center for Alzheimer's Care, Imaging and Research; 🇺🇸 Salt Lake City, Utah, United States