Dengue Seroprevalence Study in Blood Donors in the French West Indies

Completed

• Conditions: Dengue; Blood Donors

• Registration Number: NCT01104740
• Lead Sponsor: Etablissement Français du Sang, Martinique

Brief Summary

Dengue is an infectious disease most prevalent in the world. This disease is endemic in the Caribbean, with an increase in seasonal rains. Several outbreaks have been observed in recent years, in 2001, 2005 and 2007, during which further particularly virulent serotypes have emerged. The clinical expression of dengue fever is variable, ranging from no symptoms to a classical form with fever, and even of severe or lethal bleeding. With the possible existence of silent forms of the disease, there are no data identifying the current level of protection of the population in Martinique / Guadeloupe.

Detailed Description

1. Principal objective:

To estimate the prevalence of the specific antibodies of the dengue (IgG) in blood donors in the French West Indies.

2. Secondary objective:

To specify the serotypic specificity of the anti-dengue antibodies detected during the study.

Study Timeline

• Study First Submitted: 2010-04-14
• Study First Submitted QC: 2010-04-14
• Study First Posted: 2010-04-15
• Study Start: 2011-05
• Primary Completion: 2011-05
• Study Completion: 2012-05
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-16
• Last Update Posted: 2021-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 817

Inclusion Criteria

• Eligible for blood donation following the French legislation,
• Resident in Martinique /Guadeloupe for at least one year
• Consent signed

Exclusion Criteria

• Not Eligible for blood donation following the French legislation,
• Not Resident in Martinique / Guadeloupe for at least one year
• Consent not signed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence or not of dengue virus-specific immunoglobulin G antibodies	1 day

Secondary Outcome Measures

Name	Time	Method
Characterization of dengue virus serotype-specific IgG	1 day	Characterization of dengue virus serotype-psecific IgG whendengue virus serotype-specific immunoglobulin G antibodies Test is positive

Trial Locations

Locations (2)

French Blood Establishment of Guadeloupe; 🇬🇵 Pointe-à-Pitre, Guadeloupe

French Blood Establishment of Martinique; 🇲🇶 Fort-de-France, Martinique