The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers
Not Applicable
Completed
- Conditions
- Prediabetes
- Registration Number
- NCT02229487
- Lead Sponsor
- Ramathibodi Hospital
- Brief Summary
Hypothesis
1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration.
2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 51
Inclusion Criteria
- Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
- Age 18 or older
- Can understand Thai (speaking, listening and reading)
- Agree to participate by written informed consent
Exclusion Criteria
- Those who depend on others for feeding (such as stroke patients)
- Shift workers
- History of congestive heart failure or low ejection fraction
- Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
- Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
- Patients with permanent pacemaker
- History of previous stroke
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method GLP-1 Levels in Response to Oral Glucose Tolerance Test 2 weeks Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Faculty of Medicine Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Faculty of Medicine Ramathibodi Hospital🇹🇭Bangkok, Thailand