The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Not Applicable

Completed

• Conditions: Prediabetes
• Interventions: Other: Oral glucose tolerance

• Registration Number: NCT02229487
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

Hypothesis

1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration.

2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-08-28
• Study First Submitted QC: 2014-08-28
• Study First Posted: 2014-09-01
• Study Start: 2014-10
• Primary Completion: 2017-03
• Study Completion: 2017-03-31
• Results First Submitted: 2017-05-01
• Results First Submitted QC: 2017-05-01
• Results First Posted: 2017-08-14
• Status Verified: 2017-09
• Last Update Submitted: 2017-09-11
• Last Update Posted: 2017-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
2. Age 18 or older
3. Can understand Thai (speaking, listening and reading)
4. Agree to participate by written informed consent

Exclusion Criteria

1. Those who depend on others for feeding (such as stroke patients)
2. Shift workers
3. History of congestive heart failure or low ejection fraction
4. Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
5. Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
6. Patients with permanent pacemaker
7. History of previous stroke

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal Sleepers	Oral glucose tolerance	Prediabetes patients with normal sleep duration (7-8 hours/ night) as measured objectively
Short Sleepers	Oral glucose tolerance	Prediabetes patients with short sleep duration (\<6 hours/night) as measured objectively

Primary Outcome Measures

Name	Time	Method
GLP-1 Levels in Response to Oral Glucose Tolerance Test	2 weeks	Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels

Trial Locations

Locations (1)

Faculty of Medicine Ramathibodi Hospital; 🇹🇭 Bangkok, Thailand