Tissue-specific Effects of Insufficient Sleep

Not Applicable

Active, not recruiting

• Conditions: Healthy
• Interventions: Behavioral: Insufficient sleep

• Registration Number: NCT03437681
• Lead Sponsor: University of Colorado, Denver

Brief Summary

This study plans to learn more about how sleep loss impacts the way the body responds to sugar. This work will have important implications for development of treatments and countermeasures for people who are not able to get enough sleep for various reasons.

Detailed Description

Participants will stay in the hospital for 6 days and will not be able to leave. Sleep habits will be measured for 7 days before the study. A research diet that is designed to maintain weight will be provided for 3 days before the study and during the study. Multiple tests will be performed, including metabolic testing and muscle and fat biopsies, both when participants first arrive and have had normal sleep and again after 4 nights of only 5 hours time in bed. The visit takes place at the Clinical Translational Research Center (CTRC) at the University of Colorado Denver, Anschutz Medical campus. It will take approximately 2 weeks to complete this study.

Study Timeline

• Study First Submitted: 2018-02-06
• Study Start: 2018-02-12
• Study First Submitted QC: 2018-02-12
• Study First Posted: 2018-02-19
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-11-30
• Primary Completion: 2024-06-30
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Not provided

Exclusion Criteria

1. Current or history of any clinically significant medical, psychiatric, or sleep disorder.
2. Use or history of any drugs, medications, supplements, caffeine, and alcohol.
3. Current or history of shiftwork in six months prior to laboratory study.
4. Travel more than one time zone in three weeks prior to laboratory study.
5. Blood donation in the 30 days prior to inpatient study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Insufficient sleep	Insufficient sleep	Each participant will receive 4 nights of insufficient sleep.

Primary Outcome Measures

Name	Time	Method
Change in insulin sensitivity	One week	Insulin sensitivity measured by hyperinsulinemic euglycemic clamp.

Secondary Outcome Measures

Name	Time	Method
Changes in microvascular function	One week	Macrovascular function will be assessed with EndoPAT
Changes in cognitive abilities	One week	Cognitive computer tests performed during study
Changes in metabolic tissue function	One week	Tissue biopsies will be performed
Changes in macrovascular function	One week	Macrovascular function will be assessed with flow-mediated dilation
Changes in circadian rhythms	One week	Salivary dim-light melatonin offset will be assessed

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States