Tissue-specific Effects of Insufficient Sleep
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Colorado, Denver
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Change in insulin sensitivity
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study plans to learn more about how sleep loss impacts the way the body responds to sugar. This work will have important implications for development of treatments and countermeasures for people who are not able to get enough sleep for various reasons.
Detailed Description
Participants will stay in the hospital for 6 days and will not be able to leave. Sleep habits will be measured for 7 days before the study. A research diet that is designed to maintain weight will be provided for 3 days before the study and during the study. Multiple tests will be performed, including metabolic testing and muscle and fat biopsies, both when participants first arrive and have had normal sleep and again after 4 nights of only 5 hours time in bed. The visit takes place at the Clinical Translational Research Center (CTRC) at the University of Colorado Denver, Anschutz Medical campus. It will take approximately 2 weeks to complete this study.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Current or history of any clinically significant medical, psychiatric, or sleep disorder.
- •Use or history of any drugs, medications, supplements, caffeine, and alcohol.
- •Current or history of shiftwork in six months prior to laboratory study.
- •Travel more than one time zone in three weeks prior to laboratory study.
- •Blood donation in the 30 days prior to inpatient study.
Outcomes
Primary Outcomes
Change in insulin sensitivity
Time Frame: One week
Insulin sensitivity measured by hyperinsulinemic euglycemic clamp.
Secondary Outcomes
- Changes in microvascular function(One week)
- Changes in cognitive abilities(One week)
- Changes in metabolic tissue function(One week)
- Changes in macrovascular function(One week)
- Changes in circadian rhythms(One week)