Efficacy of Intense Pulsed Light Treatment in Patients With Meibomian Gland Dysfunction
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Difference Meibum quality score and expressibility between both eyes during the 6-month visit
研究概览
简要总结
Meibomian gland dysfunction (MGD) is a major cause of dry eye disease (DED). Up to 86% of patients suffering from DED also show signs of MGD. Traditional treatment of MGD is based on eye lid hygiene and massage in combination with intensive usage of lubricants.
Recently, a novel technology the intense pulsed light (IPL) therapy was introduced, which shows promising results in patients with meibomian gland dysfunction. Originating from field of dermatology, subjecting improvement of dry eye symptoms was recognized after the treatment of facial rosacea using IPL. Different hypotheses exist how IPL treatment might improve the situation in the dry eye patient. Warming of the eyelid, due to the light application and reduction of bacterial load are two possible mode of actions. Further, the used wavelengths in IPL may be modified that the light is only absorbed by oxygenated haemoglobin, which lead to an obliteration of telangiectasia and reduced inflammation on the lid margin. This principal is applied in the treatment of facial rosacea.
Aim of this study is to investigate the effect of IPL therapy in patients with MGD on dry eye parameters as well as subjective complaints.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age older than 18 years
- •Presence of meibomian gland dysfunction at any stage
- •Presence of meibomian glands on each lower eyelid's Meibography
排除标准
- •Fitzpatrick Skin Type VI
- •Usage of eye drops other than lubricants (e.g. antibiotics, steroids, cyclosporin-A)
- •Usage of systemic antibiotic therapy
- •Any pathology of the ocular surface except dry eye disease (e.g. corneal scarring, cornea ectasia)
- •Ocular surgery within prior 3 months
- •Ocular injury within prior 3 months
- •Ocular herpes of eye or eyelid within prior 3 months
- •Active ocular infection
- •Active ocular inflammation or history of chronic, recurrent ocular inflammation within prior 3 months
- •Eyelid abnormalities that affect lid function
- •Ocular surface abnormality that may compromise corneal integrity
- •Pregnancy
结局指标
主要结局
Difference Meibum quality score and expressibility between both eyes during the 6-month visit
时间窗: 6-months visit
次要结局
- Change of Ocular Surface Disease Index (OSDI) score during the study period(6 months)
- Comparison of dry eye related parameters between both eyes (tear film break up time, Oxford Staining)(6 months)
- Change of dry eye related parameters during the study period in the study eye (tear film break up time, Oxford Staining)(6 months)
研究者
Prim. Prof. Dr. Oliver Findl, MBA
Prim. Univ. Prof. Dr. Oliver Findl, MBA
Vienna Institute for Research in Ocular Surgery