Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation

Not Applicable

• Conditions: Alveolar Bone Loss
• Interventions: Procedure: Alveolar ridge preservation after extraction

• Registration Number: NCT04393714
• Lead Sponsor: Cairo University

Brief Summary

The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-14
• Study First Submitted QC: 2020-05-14
• Study First Posted: 2020-05-19
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-13
• Last Update Posted: 2020-07-15
• Study Start: 2020-10-01
• Primary Completion: 2021-08-31
• Study Completion: 2021-10-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Non-restorable teeth
• medically healthy
• able to provide informed consent and attend follow-up period

Exclusion Criteria

• pregnant
• smokers or alcoholic
• severe bone loss

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
autogenous dentin graft treated with nitric acid	Alveolar ridge preservation after extraction	-
autogenous dentin graft treated with hydrochloric acid	Alveolar ridge preservation after extraction	-

Primary Outcome Measures

Name	Time	Method
Radiographic bone changes	6 months	width and height losses (quantitative in mm)

Secondary Outcome Measures

Name	Time	Method
soft tissue healing	Biweekly for 6 weeks	rate of wound epitheliallization
histological analysis	6 months	Histologic observations (qualitative) and histomorphometric measurements (quantitative in %)