Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endocrine Disorders
- Sponsor
- IRCCS San Raffaele
- Enrollment
- 200
- Primary Endpoint
- Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue
Investigators
Andrea Giustina
Professor of Endocrinology and Metabolism
IRCCS San Raffaele
Eligibility Criteria
Inclusion Criteria
- •Obese patients affected and not by hypothalamic-pituitary diseases
Exclusion Criteria
- •Minor subjects;
- •Pregnant and/or breastfeeding women;
- •Patients suffering from states of primary and/or acquired immunodeficiencies, and/or serious impairment of general clinical conditions (e.g. metastatic neoplasms; immunosuppressive therapies; worsening/reacerbated/compensated chronic pathologies);
- •Patients unable to understand and sign the Informed Consent.
Outcomes
Primary Outcomes
Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies
Time Frame: retrospective and prospective collection of clinical data between 01/01/2021 and 31/12/2026
The study aims to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies