Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies
研究概览
简要总结
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obese patients affected and not by hypothalamic-pituitary diseases
排除标准
- •Minor subjects;
- •Pregnant and/or breastfeeding women;
- •Patients suffering from states of primary and/or acquired immunodeficiencies, and/or serious impairment of general clinical conditions (e.g. metastatic neoplasms; immunosuppressive therapies; worsening/reacerbated/compensated chronic pathologies);
- •Patients unable to understand and sign the Informed Consent.
结局指标
主要结局
Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies
时间窗: retrospective and prospective collection of clinical data between 01/01/2021 and 31/12/2026
The study aims to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies
次要结局
未报告次要终点
研究者
Andrea Giustina
Professor of Endocrinology and Metabolism
IRCCS San Raffaele