Clinical, Hematological, and Imagiologic Predictors of Postoperative Complications and Long Term Cardiovascular Events After Carotid Endarterectomy With Regional Anesthesia
试验速览
- 阶段
- 不适用
- 入组人数
- 272
- 试验地点
- 1
- 主要终点
- Stroke
研究概览
简要总结
Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.
详细描述
The authors hypothesize FGF-23 and GDF-15 could predict cerebral ischemia, postoperative complications and long term major cardiovascular events, particularly in patients developing symptomatic neurologic ischemia after circulation shutdown.
Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.
Clarify the pathophysiology of carotid endarterectomy-related stroke and the role of GDF-15, FGF-23, BNP and hs-troponin I and other biomarkers in the prognosis of symptomatic carotid stenosis.
Imagiologic markers are to be included - intima-media; gray weale plaque classification, cerebral CT Peak wave velocity
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consecutive patients from a tertiary referral center who undergo CEA for carotid artery stenosis (CS) under regional anesthesia
排除标准
- •general anesthesia
- •carotid stenting
结局指标
主要结局
Stroke
时间窗: 30 days, long-term
Clavien dindo>3
时间窗: 30 days, long-term
MACE
时间窗: 30 days, long-term
AMI, stroke, Major adverse limb event, acute hear faillure hospitalization, all cause mortality
次要结局
未报告次要终点
研究者
João Rocha Neves
MD, MSC; MPH, FEBVS
Universidade do Porto