Cocaine Use Disorder and Cortical Dopamine
Early Phase 1
Completed
- Conditions
- Cocaine Dependence
- Interventions
- Radiation: [C-11]FLB 457
- Registration Number
- NCT03349606
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
The goal of this study is to use \[C-11\]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
- Detailed Description
This study seeks to examine dopamine (DA) transmission in vivo, using positron emission tomography (PET) with \[C-11\]FLB 457, in cortical regions of interest in subjects who have a history of cocaine dependence. We hypothesize that cocaine dependence is associated with decreases in dopamine in the prefrontal cortical regions compared to controls. This may explain the impulsivity and cognitive deficits that underlie relapse in this disorder.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cocaine dependence [C-11]FLB 457 \[C-11\]FLB 457 PET at baseline and post d-amphetamine Controls [C-11]FLB 457 \[C-11\]FLB 457 PET at baseline and post d-amphetamine Cocaine dependence d-amphetamine \[C-11\]FLB 457 PET at baseline and post d-amphetamine Controls d-amphetamine \[C-11\]FLB 457 PET at baseline and post d-amphetamine
- Primary Outcome Measures
Name Time Method Percent change in Binding potential (BPnd) Baseline BPnd (time 0) and Post-amphetamine BPnd (time 3 hours) DELTA BPnd
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of PIttsburgh PET Facility
🇺🇸Pittsburgh, Pennsylvania, United States