Iontophoresis as a possible therapy for digital ischaemia

Completed

• Conditions: Topic: Skin, Musculoskeletal; Subtopic: Musculoskeletal (all Subtopics), Skin (all Subtopics); Disease: Musculoskeletal, Dermatology; Skin and Connective Tissue Diseases; Scleroderma spectrum disorders

• Registration Number: ISRCTN84211155
• Lead Sponsor: Salford Royal NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05-12
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

1. A diagnosis of SSc (or of another scleroderma-spectrum disorder)
2. Severe digital ischaemia
3. Digital ulceration severe enough to require hospitalisation for intravenous prostanoid therapy
4. Aged 18 - 80 years, either sex

Exclusion Criteria

1. Aged less than 18 or greater than 80 years
2. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase in perfusion; one laser Doppler image will be taken before and after treatment on days 1, 2 and 5 where possible.

Secondary Outcome Measures

Name	Time	Method
1. Modified Scleroderma Health Assessment Questionnaire (SHAQ); these will be filled out by patients at the start and end of the 5 day treatment period<br>2. Patient opinion, measured at the end of the 5 day treatment period