The effects of positive end-expiratory pressure on the position, length and function of the diaphragm
Completed
- Conditions
- N/A1002830210038716
- Registration Number
- NL-OMON46488
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 18
Inclusion Criteria
Signed informed consent
Age * 18 years
Exclusion Criteria
Symptoms relating to respiratory or cardiovascular disease
History of pneumothorax or family history of primary pneumothorax
Obesity (BMI > 30)
Known pregnancy
Contraindications for the placement of a nasogastric tube (Upper airwau/esophageal/gastric/mouth or face pathology, nasal bleeding within the last 2 weeks or use of anticoagulants)
Contraindictions for MRI (Electrical/metallic implants, claustrophobia, history in metalworking)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The first main parameter is the change in the position of the diaphragm during<br /><br>different PEEP levels, as measured with both ultrasound and MRI. The second<br /><br>parameter is the changes in neuro-mechanical efficiency of the diaphragm (ratio<br /><br>between pressure and electrical muscle activity) during different PEEP levels,<br /><br>as measured with a nasogastric catheter. Furthermore, twitch transdiaphragmatic<br /><br>pressures during different PEEP levels, as measured with magnetic stimulation<br /><br>of the phrenic nerves, will be monitored. At last, changes of the diaphragm*s<br /><br>shape and length during different PEEP levels, as measured with MRI will be<br /><br>used.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters is the difference between diaphragm parameters<br /><br>obtained by ultrasound and parameters obtained by MRI.</p><br>