Effect of Intravenous Versus Inhalational Anaesthetic agent on Oxygenation in Patients undergoing Thoracic Surgery

Not yet recruiting

• Conditions: Chronic obstructive pulmonary disease, unspecified, (2) ICD-10 Condition: J869||Pyothorax without fistula,

• Registration Number: CTRI/2022/10/046752
• Lead Sponsor: Sir Gangaram Hospital

Brief Summary

Intravenous propofol and various inhalational anaesthetic agents are the key components of modern general anaesthesia. Advances in thoracic surgery have been possible with the use of these modern anaesthetic agents.

One lung ventilation (OLV) is indicated for thoracic surgical procedures, for prevention of cross-contamination of the lungs and to control the distribution of ventilation.

However, during OLV, hypoxemia remains a major concern in the management of anaesthesia for thoracic surgery, due to pulmonary arteriovenous shunting of unsaturated pulmonary venous blood. Hypoxic pulmonary vasoconstriction acts as a defence mechanism against shunting. Therefore, in thoracic surgery, anaesthetics with minimal inhibitory effect on HPV and minimal haemodynamic changes are preferred. By limiting intrapulmonary shunting, the fall in arterial oxygen pressure can be attenuated, thus allowing better patient outcome.

This randomized study aims to evaluate the effect of two major anaesthetic agents, propofol and sevoflurane on arterial oxygenation during one lung ventilation in adults undergoing elective right sided open thoracic surgery.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-10-26
• Study Start: 2022-10-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 1 Age of patient between 18-70 years.
• 2 All consenting patients to undergo open thoracic surgery.
• 3 American Society of Anaesthesiologist (ASA) physical status between 1-3.
• 4 Patients with unilateral lung pathology undergoing thoracic surgery.

Exclusion Criteria

• 1 Patients with bilateral pulmonary pathology.
• 2 Patients with baseline SpO2 < 90% at room air.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the Arterial Oxygenation PaO2 by serial ABG, in both the groups.	ABG to be taken at 5 predetermined time points, that is at 10 minutes of Two-lung ventilation after induction, then at 15,30,60 and 90 minutes after the start of One-lung ventilation.

Secondary Outcome Measures

Name	Time	Method
To compare Cardiac Output and Stroke Volume	10 minutes of Two-lung ventilation, then at 15,30,60 and 90 minutes after the start of One-lung ventilation.

Trial Locations

Locations (1)

Sir Gangaram Hospital; 🇮🇳 Central, DELHI, India

Sir Gangaram Hospital

🇮🇳Central, DELHI, India

Nadia Ahmad

Principal investigator

9538035310

ahmad.nadia24@gmail.com