Effect of vitamin C infusion on aldosterone and renin levels and erythrocyte sedimentation rate

Not Applicable

Recruiting

Conditions: adrenal glands Suppression.
Disorder of adrenal gland, unspecified
E27.9

Registration Number: IRCT20180107038251N5

Lead Sponsor: Arak University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 102

Inclusion Criteria

Patients aged 25-70 years
Patients with American Society of Anesthesiologists (ASA) class 1 and 2
Patients candidate for elective laparotomy surgery

Exclusion Criteria

Patients with severe debilitating disease
Patients with blood disorders
Renal and hepatic impairment, diabetes, severe septic shock or sepsis, Addison or Cushing's disease, epilepsy
Alcohol abuse
smokers
Pregnant women
trauma
Severe allergy to any of the drugs used
Patients with a history of corticosteroid use with a dose that can suppress the pituitary-adrenal cortisol axis
Severe hemodynamic changes during surgery
Duration of surgery more than 4 hours
The patient's unwillingness to participate in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aldosterone. Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.;Renin. Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.;ESR (Erythrocyte Sedimentation Rate). Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.

Secondary Outcome Measures

Name	Time	Method
Oxygen saturation. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.;Heart rate. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.;Blood pressure. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.