A Randomized Phase III Trial Of Gemcitabine Plus Bevacizumab (NSC#704865 IND#7621) Versus Gemcitabine Plus Placebo In Patients With Advanced Pancreatic Cancer

National Cancer Institute (NCI)1 site in 1 country590 target enrollmentStarted: June 2004Last updated: June 5, 2013

Conditions

Interventions

Drugs

Trial Snapshot

Phase: Phase 3
Status: Completed
Sponsor: National Cancer Institute (NCI)
Enrollment: 590
Locations: 1
Primary Endpoint: Overall survival (OS)

Study Overview Study Design Eligibility Criteria Arms & Interventions Outcomes Investigators Sites Records & Identifiers Similar Trials

Study Overview

Brief Summary

This randomized phase III trial is studying gemcitabine and bevacizumab to see how well they work compared to gemcitabine alone in treating patients with locally advanced or metastatic pancreatic cancer. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as bevacizumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Bevacizumab may also stop the growth of tumor cells by stopping blood flow to the tumor. Combining gemcitabine with bevacizumab may kill more tumor cells. It is not yet known whether gemcitabine is more effective with or without bevacizumab in treating pancreatic cancer.

Detailed Description

PRIMARY OBJECTIVES:

I. To determine if combination chemotherapy with gemcitabine and bevacizumab achieves superior survival compared to gemcitabine and placebo in patients with previously untreated advanced pancreatic cancer.

SECONDARY OBJECTIVES:

I. To compare the objective response rates, duration of response, progression free survival, and toxicity of these two regimens in patients with advanced pancreatic cancer.

II. To measure baseline levels of VEGF and correlate with treatment outcome. III. To measure baseline and on treatment levels of additional growth factors that may be co- or counter- regulated with VEGF and correlate with response to treatment.

Study Design

Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel
Primary Purpose: Treatment
Masking: Double (Participant, Investigator)

Eligibility Criteria

Ages: 18 Years to — (Adult, Older Adult)
Sex: All
Accepts Healthy Volunteers: No

Inclusion Criteria

•Histologic or cytologic documentation of adenocarcinoma of the pancreas; documentation of disease extent by CT scan is required; radiologically measurable disease is not required; patients with documented invasion of adjacent organs (e.g., duodenum, stomach) by CT scan are not eligible
•No prior chemotherapy for metastatic disease
•If the patient received adjuvant therapy, it must have been completed at least 4 weeks prior to enrollment on this study; the patient must have recovered from all treatment related toxicities and must have evidence of disease progression following adjuvant treatment
•Prior radiation therapy, with or without a radiosensitizing dose of fluoropyrimidines, is allowed provided the patient has disease outside of the radiation port; at least 4 weeks must have elapsed from completion of the radiation therapy and all signs of toxicity must have resolved
•No prior treatment with gemcitabine or bevacizumab in the adjuvant or metastatic setting
•No current or recent (within 1 month) use of a thrombolytic agent
•Patients may not have had prior therapy with other VEGF inhibitors
•No recent invasive surgical procedures; this includes:
•Major surgical procedure (e.g. exploratory laparotomy or laparoscopy), open biopsy, or significant traumatic injury within 28 days prior to registration
•Fine needle aspirations or venous access device within 7 days prior to registration
•Anticipation of need for major surgical procedures during the course of the study
•No clinically significant cardiovascular disease; this includes:
•Uncontrolled hypertension (blood pressure > 150/90 on medication)
•New York Heart Association grade II or greater congestive heart failure
•Serious cardiac arrhythmia requiring medication
•No recent (within 6 months) arterial thrombotic events, including transient ischemic attack (TIA), cerebrovascular accident (CVA), unstable angina, or myocardial infarction (MI); patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are also ineligible
•No evidence of CNS disease, including primary brain tumor, or any brain metastasis
•No serious or non-healing wound, ulcer or bone fracture
•No serious active infection (viral, fungal bacterial); no infection requiring parenteral antibiotics at time of registration
•Patients with known hypersensitivity of Chinese hamster ovary cell products or other recombinant human antibodies are not eligible
•Patients with a "currently active" second malignancy other than non-melanoma skin cancers are not to be registered; patients are not considered to have a "currently active" malignancy if they have completed therapy and considered by their physician to be at less than 30% risk of relapse
•Women must be non-pregnant and non-breast feeding
•ECOG Performance status of 0, 1 or 2
•Granulocytes ≥ 1,500/μl
•Platelet count ≥ 100,000/μl
•Creatinine ≤ 1.5 mg/dL or creatinine clearance ≥ 60 mL/min
•Total bilirubin ≤ 1 x upper limit of normal
•SGOT(AST) ≤ 2.5 x upper limit of normal
•PT INR =< 1.5, unless patient is on full dose warfarin
•Urine protein; for ≥ 1+ proteinuria, 24 hour urine collection must demonstrate < 1 gm of protein/24 hours
•Required diagnostic procedures:
•CT of the abdomen
•Chest x-ray

Exclusion Criteria

Not provided