Efficacy of Helicobacter pylori eradication followed by sequential administration of proton pump inhibitor and proton pump inhibitor plus prokinetic for the patients with dyspepsia
- Conditions
- patients with dyspepsia and H.pylori infection
- Registration Number
- JPRN-UMIN000012827
- Lead Sponsor
- Okayama University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 200
Not provided
1) patients with past history of gastrectomy 2) patients with alarm symptom auch as vomiting, gastrointestinal hemorrhage, and rapid body weight loss 3) reflux esophagitis (> and = Los Angeles grade A) or peptic ulcer 4) patients with the following diseases or previous history: Zollinger-Ellison syndrome; inflammatory bowel disease; esophageal stenosis; Achalasia; and organic disease in the brain 5) severe diseases in liver, kidney, and heart 6) persons with malignancy or possibility of malignancy 7) expect muther, mother with breast-feeding 8) under administration of atazanavir sulfate 9) drug allegy for penicillin 10) administration the following drugs within 2 weeks: proton pump inhibitors; histamine 2-receptor antagonists; and prokinetics 11) other not applicable person recognized by a doctor
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) overall evaluation for each treatment by patients 2) evaluation of symptom index (modified F scale) at baseline, post 4 weeks treatment of rabeprazole, and post 4 weeks treatment of rabeprazole plus acotiamide
- Secondary Outcome Measures
Name Time Method 1) assessment of the symptom factors that influence the efficacy during the treatment from the symptom index (modified F scale) 2) patients'QOL by using SF 8 scale at baseline, post 4 weeks treatment of rabeprazole, and post 4 weeks treatment of rabeprazole plus acotiamide