The Neural Substrates for Working Memory Training

Phase 2

• Conditions: Rehabilitation; Working Memory
• Interventions: Behavioral: Working memory training

• Registration Number: NCT03012269
• Lead Sponsor: China Rehabilitation Research Center

Brief Summary

This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2016-12-31
• Status Verified: 2017-01
• Study First Submitted QC: 2017-01-04
• Last Update Submitted: 2017-01-04
• Study First Posted: 2017-01-06
• Last Update Posted: 2017-01-06
• Primary Completion: 2018-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Right handedness
• Diagnosis of traumatic brain injury or stroke
• Course of disease within one year
• The score of MoCA test > 24
• Able to understand instructions

Exclusion Criteria

• Aphasia, unilateral spatial neglect, agnosia, apraxia
• Hearing impairment or visual impairment
• History of taking psychiatric drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Working Memory Training	Working memory training	The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.

Primary Outcome Measures

Name	Time	Method
Training-induced brain activations during working memory tasks in fMRI	six weeks	Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline

Secondary Outcome Measures

Name	Time	Method
Attention ability assessed by Stroop color-word test	six weeks
The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test	six weeks

Trial Locations

Locations (1)

Department of Rehabilitation Evaluation, China Rehabilitation Research Center; 🇨🇳 Beijing, Beijing, China