The Imaging Genetic Study of Type 2 Diabetes and Depression

• Conditions: T2DM
• Interventions: Device: Magnetic resonance

• Registration Number: NCT03564431
• Lead Sponsor: Kunming Medical University

Brief Summary

To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Detailed Description

Diabetes and depression are harmful to human health,but they often co-exist.At present, the pathophysiological mechanisms underlying the comorbidity of diabetes and depression are discussed, including hypothalamic-pituitary-adrenal axis dysfunction, inflammation, epigenetics, disturbed circadian rhythms, environmental and behavioral factors,neuroimaging,etc.the purpose of the investigator's study is to investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Study Timeline

• Study Start: 2017-12-01
• Study First Submitted: 2018-06-11
• Study First Submitted QC: 2018-06-19
• Study First Posted: 2018-06-20
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-15
• Last Update Posted: 2019-09-17
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

conform to type 2 diabetes, depression, diagnostic criteria of unrelated normal controls the han nationality patients; Aged 30 to 70 years of age, gender not limited; The patient or legal guardian have signed informed consent of patients.

Exclusion Criteria

Magnetic resonance imaging has the contraindication, such as metal implants, claustrophobic, etc.

With severe body diseases, including inflammatory diseases and autoimmune diseases; Current or past history of nervous system disease or brain injury. Merge other severe mental illness or existing psychotic symptoms; Always have a mania, hypomania attack; Has a history of substance abuse; Pregnant women and nursing mothers; Estimated compliance is poorer, not partners; Is being treated for a mental drug therapy, and ECT, TMS; Patients with a body mass index > 35; There are currently no taking corticosteroids, immune regulator, etc. Now or ever did not suffer from patients with other diagnosis to the dsm-iv axis I; Merge the endocrine system disease, thyroid, adrenal gland and pituitary gland diseases, etc.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
controls	Magnetic resonance	-
T2DM patients	Magnetic resonance	-
depression patients	Magnetic resonance	-
T2DM with depression patients	Magnetic resonance	-

Primary Outcome Measures

Name	Time	Method
the neuroimaging of Type 2 Diabetes and Depression	from 2017-12 to 2019-12	the structure and function of Abnormalities in the T2DM Patients

Trial Locations

Locations (1)

Psychiatry department, The 1st Affiliated Hospital of Kunming Medical University; 🇨🇳 Kunming, Yunnan, China