NCT01639391已完成不适用
Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Success of fibroblast culture, amplification, and freezing pellets
研究概览
简要总结
Patients with ALS will be included in the reference center for ALS in hospital La Pitié Salpêtrière, Paris.
The study proposes to investigate the pathophysiology of ALS by setting up a fibroblast bank for studying molecular, cellular and genetic parameters of the pathology.
iPS (induced pluripotent stem cells) and then differentiated cells will be generated.
The pathophysiology of ALS will be studied on the 3 types of cells (fibroblasts, iPS, differentiated cells).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients over 18 years old
- •ALS sporadic or familial or unknown
排除标准
- •known cutaneous disease not allowing the biopsy
- •platelets less than 10 000/m3
- •suspected or known xylocain allergy
研究组 & 干预措施
patients
Experimental
干预措施: skin biopsy (Procedure)
结局指标
主要结局
Success of fibroblast culture, amplification, and freezing pellets
时间窗: 2 months
次要结局
- Induced pluripotent Stem Cells generation success(2 years)
- neurones, motoneurones, glial cells obtention from fibroblasts or iPS(2 years)
研究者
研究点 (2)
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