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Clinical Trials/SLCTR/2014/007
SLCTR/2014/007
Terminated
未知

Double blind randomized placebo controlled trial of corticosteroids and doxycycline in the treatment of interstitial nephritis

one0 sites200 target enrollmentTBD
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ConditionsAcute interstitial nephritis

Overview

Phase
未知
Intervention
Not specified
Conditions
Acute interstitial nephritis
Sponsor
one
Enrollment
200
Status
Terminated
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Sponsor
one

Eligibility Criteria

Inclusion Criteria

  • •1\.Two or more elevated (value more than upper limit of the normal) serum creatinine values done within 3 days and
  • •2\.Normal size kidneys defined as more than 9 cm longitudinal diameter and normal anatomy on ultrasound scan
  • •3\. Age less than 60 years

Exclusion Criteria

  • •1\.History of chronic kidney disease, diabetes mellitus, chronic hypertension, connective tissue diseases, vacuities,hyperuricemia, pyelonephritis, renal stone disease and any obstructive uropathy, polycystic kidney disease or any other known genetic disease, glomerular nephritides, snake bite, and childhood renal disease.
  • •2\.Whose current abnormal creatinine is explainable by recent exposure to nephrotoxic drugs (non\-steroidal anti\-inflammatory drugs, gentamicin…etc.) or toxins.
  • •3\.BP \>160/100mmhg untreated or \>140/90 on up to two antihypertensives
  • •4\.Two or more fasting blood sugar more than 7 mmol/l
  • •5\.UFR showing red blood cells more 50 per HPF with more than 80% dysmorphic cells or nephrotic range proteinuria or pus cells more than 100 per HPF with a positive urine culture
  • •6\.Ultrasound scan revealing unilateral renal involvement

Outcomes

Primary Outcomes

Not specified

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