Exercise Training in Children and Adults: Mechanisms of Allaying Inflammation in Asthma
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Locations
- 2
- Primary Endpoint
- Gene and microRNA expression will be compared between healthy and asthmatic subjects
Study Overview
Brief Summary
The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 8 Years to 35 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Good health
- •Physical activity
- •No evidence of disease or disability
- •Diagnosed with persistent asthma (asthma subjects)
- •BMI<95 percentile
Exclusion Criteria
- •Use of illegal drugs or alcohol
- •Very high physical fitness
- •Pregnancy
- •More than two asthma attack per week (asthma subjects)
Outcomes
Primary Outcomes
Gene and microRNA expression will be compared between healthy and asthmatic subjects
Time Frame: 12 weeks
Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls
Secondary Outcomes
- Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups(12 weeks)