Preventive Cognitive Therapy with Neurocognitive Remediation Therapy for partially remitted depressed patients

Recruiting

• Conditions: 10027946; Depression; Major Depressive Disorder

• Registration Number: NL-OMON55338
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 115

Inclusion Criteria

Does not meet the criteria of a current MDD episode according to the DSM-5, as
assessed with the SCID-5-S;
Is at least 8 weeks MDD diagnosis-free (with a maximum of 2 years);
Has a HAM-D score of >=8 and <=15;
Is aged 18 or older;
Speaks Dutch or English.

Exclusion Criteria

- Current (hypo)mania or a history of bipolar illness;
- Any psychotic disorder;
- Alcohol or drug misuse;
- Primary Anxiety disorder diagnosis;
- Electroconvulsive therapy in the previous 12 months;
- Neurological disorder;
- Disabling sensory and/or motor deficit.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter will be assessed monthly during a one-year period after<br /><br>baseline assessment using the Inventory of Depressive Symptomatology (IDS-SR). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objectives are to investigate the effectiveness of PCT plus<br /><br>oNCRT, compared to PCT only, in patients partially remitted from depression on:<br /><br>Neuropsychological functioning (Verbal learning: immediate and delayed memory<br /><br>recall; Mental flexibility (inhibition and set-shifting ability); Verbal<br /><br>working memory; Planning)<br /><br>Positive and negative affect, dysfunctional attitudes, and stress<br /><br>Time to MDD relapse within a year from baseline<br /><br>Disability<br /><br>Health-related quality of life<br /><br>Health care and associated costs and costs from productivity loss</p><br>