Comparison of Brovavir Versus Acyclovir in the Treatment of Herpes in HIV-Infected Patients
- Conditions
- HIV InfectionsChickenpox
- Registration Number
- NCT00000953
- Brief Summary
To compare the efficacy of oral sorivudine (brovavir) and oral acyclovir for the treatment of localized herpes zoster in HIV-infected patients.
HIV-infected patients are at high risk for herpesvirus infections, including varicella-zoster virus ( VZV ) infections, also called shingles. Acyclovir, an approved drug, is widely used to treat VZV infections in the HIV population. Since no data from controlled studies are available to define the role of antiviral therapy for VZV infections in HIV-infected patients, a study is needed to test the relative efficacy of brovavir, an experimental antiviral drug, versus that of acyclovir.
- Detailed Description
HIV-infected patients are at high risk for herpesvirus infections, including varicella-zoster virus ( VZV ) infections, also called shingles. Acyclovir, an approved drug, is widely used to treat VZV infections in the HIV population. Since no data from controlled studies are available to define the role of antiviral therapy for VZV infections in HIV-infected patients, a study is needed to test the relative efficacy of brovavir, an experimental antiviral drug, versus that of acyclovir.
One hundred-eighty patients are randomized to receive either brovavir or acyclovir as follows: brovavir or its matching placebo once daily and acyclovir or its matching placebo five times daily. Treatment continues for 10 days. Entry into the study must occur within 72 hours of lesion development. Patients are followed in person daily or at regular intervals during study drug administration and on days 14, 21, and 28, and then monthly by telephone for 11 months thereafter.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 180
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (44)
Med College of Georgia
🇺🇸Augusta, Georgia, United States
UCLA Med Ctr
🇺🇸Los Angeles, California, United States
Veterans Administration Med Ctr
🇺🇸Martinez, California, United States
Ohio State Univ / ACTU-Univ Clinic
🇺🇸Columbus, Ohio, United States
Dallas Veterans Administration Med Ctr
🇺🇸Dallas, Texas, United States
Univ of Texas, Southwestern Med Ctr of Dallas
🇺🇸Dallas, Texas, United States
Univ TX Galveston Med Branch
🇺🇸Galveston, Texas, United States
Massachusetts Gen Hosp / Harvard Med School
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hosp
🇺🇸Boston, Massachusetts, United States
New England Deaconess Hosp
🇺🇸Boston, Massachusetts, United States
San Diego Naval Hosp
🇺🇸San Diego, California, United States
Univ Dermatology Associates
🇺🇸Cincinnati, Ohio, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Univ TX San Antonio Health Science Ctr
🇺🇸San Antonio, Texas, United States
Univ of Washington
🇺🇸Seattle, Washington, United States
Veterans Administration Med Ctr / Community AIDS Program
🇺🇸Washington, District of Columbia, United States
Univ of Colorado Health Sciences Ctr
🇺🇸Denver, Colorado, United States
Mount Zion Med Ctr
🇺🇸San Francisco, California, United States
Natl Institutes of Health / NIAID
🇺🇸Bethesda, Maryland, United States
Portland Veterans Adm Med Ctr / Rsch & Education Grp
🇺🇸Portland, Oregon, United States
Univ of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Univ of Southern California / LA County USC Med Ctr
🇺🇸Los Angeles, California, United States
Infectious Disease Med Group
🇺🇸Oakland, California, United States
George Washington Univ Med Ctr
🇺🇸Washington, District of Columbia, United States
Rush Presbyterian - Saint Luke's Med Ctr
🇺🇸Chicago, Illinois, United States
Johns Hopkins Hosp
🇺🇸Baltimore, Maryland, United States
Beth Israel Hosp
🇺🇸Boston, Massachusetts, United States
Washington Univ
🇺🇸St Louis, Missouri, United States
Mount Sinai Med Ctr
🇺🇸New York, New York, United States
Beth Israel Med Ctr
🇺🇸New York, New York, United States
SUNY / Health Sciences Ctr at Stony Brook
🇺🇸Stony Brook, New York, United States
Mem Sloan - Kettering Cancer Ctr
🇺🇸New York, New York, United States
Carolinas Med Ctr
🇺🇸Charlotte, North Carolina, United States
Saint Luke's - Roosevelt Hosp Ctr
🇺🇸New York, New York, United States
SUNY / Health Sciences Ctr at Syracuse
🇺🇸Syracuse, New York, United States
Dayton Veterans Administration Med Ctr
🇺🇸Dayton, Ohio, United States
Med College of Ohio
🇺🇸Toledo, Ohio, United States
Scott and White Hosp
🇺🇸Temple, Texas, United States
Univ of Virginia Health Sciences Ctr
🇺🇸Charlottesville, Virginia, United States
Salem Veterans Administration Med Ctr
🇺🇸Salem, Virginia, United States
Virginia Clinical Research Inc
🇺🇸Norfolk, Virginia, United States
Great Lakes Hemophilia Foundation
🇺🇸Wauwatosa, Wisconsin, United States
Univ of Hawaii / Leahi Hosp
🇺🇸Honolulu, Hawaii, United States
Univ of New Mexico
🇺🇸Albuquerque, New Mexico, United States