It is a study to compare two intravenous fluids in patients of head injury undergoing surgery using normal saline and isotonic balanced crystalloid
Phase 2
- Conditions
- Health Condition 1: S062- Diffuse traumatic brain injuryHealth Condition 2: S066- Traumatic subarachnoid hemorrhageHealth Condition 3: S065- Traumatic subdural hemorrhage
- Registration Number
- CTRI/2020/09/027624
- Lead Sponsor
- Department of Anaesthesiology and Critical Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
patients of either sex scheduled to undergo emergency craniotomy for traumatic brain injury will be enrolled
Exclusion Criteria
associated injuries (long bone fracture, thoracic or abdominal injuries), renal or coagulation dysfunctions, electrolyte imbalance, hemodynamic instability, pregnancy and lactation, difficult airway, comorbidities will be excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects on renal functions{blood urea, serum creatinine, serum electrolytes and neutrophil gelatinase-associated lipocalin(NGAL)} <br/ ><br>acid base equilibrium(pH, base excess and bicarbonate)Timepoint: baseline, induction of anaesthesia, surgical incision, bone flap removal, 1 hour after starting of surgery, closure of skin, shifting to PACU, 12 hours and 24 hours after shifting
- Secondary Outcome Measures
Name Time Method serum osmolarity <br/ ><br>coagulation profile(Prothrombin time, Partial thromboplastin time, International normalised ratio)Timepoint: baseline, induction of anaesthesia, surgical incision, bone flap removal, 1 hour after starting of surgery, closure of skin, shifting to PACU, 12 hours and 24 hours after shifting