Comparison the effect of intravenous analgesia by paracetamol versus fentanyl in patients undergo coronary heart surgery

Phase 2

• Conditions: Coronary artery bypass.; Atherosclerotic heart disease; I25, I25.0

• Registration Number: IRCT2016121131351N1
• Lead Sponsor: Vice chancellor for research, Zahedan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Main inclusion criteria: pre-operation ejection fraction above 30%; class one to three of ASA; no simultaneous heart valves involvement; no need of intra-aort pump usage during the operation. Main exclusion criteria: positive history of sensitivity to study drugs; uncontrolled systemic disease such as diabetes; addiction to alcohol and drugs; positive history of psychologic disease and depression; asthma and other hypersensitivity reactions; fracture of sternum and ribs intraoperation; pre-operative liver enzymes rising higher than two folds; other chest pain causes other than coronary arteries; presence of neurologic signs and symptoms; any type of consciousness impairment pre-operation.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperation pain. Timepoint: Two houres, four houres, eight houres, 12 houres and 24 houres after surgery. Method of measurement: VAS Criteria.;Mean arterial pressure. Timepoint: Up to 24 hours after surgery in intervals of every 4 hours. Method of measurement: Millimeter of mercury.;Heart rate. Timepoint: Up to 24 hours after surgery in intervals of every 4 hours. Method of measurement: Beats in minute.