The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A
- Conditions
- H1N1 Influenza
- Interventions
- Drug: Vitamin (vitamin A 15 mg,C 500 mg, E 400IU)Drug: Placebo (digestive tablet)
- Registration Number
- NCT01127282
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Influenza continues to inflict an important burden on health-care systems. The 2009 H1N1 influenza virus first appeared in Mexico and the United States in March and April 2009 and has swept the globe with unprecedented speed.
The aim of this study is to evaluate effect of supplement vitamin on the clinical course of patients with acute respiratory illness suspected novel H1N1 infection.
- Detailed Description
Patients with acute respiratory illness randomized to control or vitamin groups. The patients completed questionnaire about their initial symptom scores. After 5 days of vitamin trial, patients were asked about their symptom by telephone survey.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 180
- Age > 20 years
- Acute respiratory illness suspected H1N1 infection
- Acute febrile respiratory illness(BT > 37.8) and throat pain or cough or nasal congestion
- Pregnancy
- Hypersensitivity to vitamin A
- History of liver disease or renal disease
- Urinary stone disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vitamin Vitamin (vitamin A 15 mg,C 500 mg, E 400IU) Vitamin(vitamin A 15mg,C 500mg,E 400IU) 1T po for 5 days in addition to anti-viral agent and antipyretics Control Placebo (digestive tablet) Placebo(digestive tablet) 1T po for 5 days in addition to anti-viral agent and antipyretics
- Primary Outcome Measures
Name Time Method change of symptom score 1 week after initial visit
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center
🇰🇷Seoul, Korea, Republic of