Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX

• Conditions: Sarcoma

• Registration Number: NCT00900211
• Lead Sponsor: The Christie NHS Foundation Trust

Brief Summary

RATIONALE: Collecting and storing samples of tumor tissue from patients with soft tissue sarcoma to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory is collecting tissue samples from patients with soft tissue sarcoma of the arms, hands, legs, or feet treated on clinical trial CRUK-VORTEX.

Detailed Description

OBJECTIVES:

* Determine early in the course of treatment which patients treated on clinical trial CRUK-VORTEX have an increased likelihood of distant metastases so as to highlight individuals who might benefit from early adjuvant systemic therapy.

OUTLINE: This is a multicenter study.

Tumour and normal tissue samples will be taken at the time of surgery during treatment on clinical trial CRUK-VORTEXand preserved for future microarray analyses. Tissue microarrays will be produced from both tumor and normal tissues. Blood samples will be collected for future DNA analysis.

Study Timeline

• Study Start: 2007-08
• Status Verified: 2008-04
• Study First Submitted: 2009-05-09
• Study First Submitted QC: 2009-05-09
• Study First Posted: 2009-05-12
• Primary Completion: 2012-03
• Last Update Submitted: 2013-08-23
• Last Update Posted: 2013-08-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increased likelihood of distant metastases

Trial Locations

Locations (12)

Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust; 🇬🇧 Birmingham, England, United Kingdom

Royal Orthopedic Hospital NHS Trust; 🇬🇧 Birmingham, England, United Kingdom

Bristol Haematology and Oncology Centre; 🇬🇧 Bristol, England, United Kingdom

Gloucestershire Oncology Centre at Cheltenham General Hospital; 🇬🇧 Cheltenham, England, United Kingdom

Royal National Orthopaedic Hospital NHS Trust; 🇬🇧 Cheltenham, England, United Kingdom

Middlesex Hospital; 🇬🇧 London, England, United Kingdom

Christie Hospital; 🇬🇧 Manchester, England, United Kingdom

Nottingham City Hospital; 🇬🇧 Nottingham, England, United Kingdom

Cancer Research Centre at Weston Park Hospital; 🇬🇧 Sheffield, England, United Kingdom

Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust; 🇬🇧 Shropshire, England, United Kingdom

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