Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia
- Registration Number
- NCT02647892
- Lead Sponsor
- University of Nebraska
- Brief Summary
The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.
- Detailed Description
Once the site is chosen, the skin will be anesthetized as usual. This study will utilize a commercially prepared 1% lidocaine solution mixed with standard sodium bicarbonate. A total of 10 mL will be used.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
- adults presenting for routine thyroid biopsy, paracentesis or thoracentesis in interventional radiology
Exclusion Criteria
- Patients requiring sedation
- Patients with altered mental status
- Children
- Patients allergic to lidocaine or sodium bicarbonate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A lidocaine 10 mg/mL lidocaine; Frequency: 1 Arm C sodium bicarbonate 7.5 mg/Ml of 25% sodium bicarbonate-75% lidocaine Frequency: 1 Arm B sodium bicarbonate 9 mg/mL of 10% sodium bicarbonate-90% lidocaine; Frequency: 1 Arm B lidocaine 9 mg/mL of 10% sodium bicarbonate-90% lidocaine; Frequency: 1 Arm C lidocaine 7.5 mg/Ml of 25% sodium bicarbonate-75% lidocaine Frequency: 1 Arm D lidocaine 5 mg/mL 50% sodium bicarbonate-50% lidocaine Frequency: 1 Arm D sodium bicarbonate 5 mg/mL 50% sodium bicarbonate-50% lidocaine Frequency: 1
- Primary Outcome Measures
Name Time Method Injection pain 6 months numeric pain scale
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States