NCT00083083Unknown2 期
Positron Emission Tomography Pre- and Post-treatment Assessment For Locally Advanced Non-Small Cell Lung Carcinoma
适应症
相关药物
试验速览
- 阶段
- 2 期
- 入组人数
- 250
- 试验地点
- 98
- 主要终点
- Relationship of survival to post-treatment peak standardized uptake value (SUV) as determined by the imaging institution
研究概览
简要总结
RATIONALE: Imaging procedures, such as fludeoxyglucose F18 positron emission tomography (^18FDG-PET), may improve the ability to detect disease progression and help doctors predict a patient's response to treatment and plan more effective treatment.
PURPOSE: This phase II trial is studying how well ^18FDG-PET imaging works in detecting disease progression and determining response to treatment in patients who are undergoing chemoradiotherapy for locally advanced non-small cell lung cancer.
详细描述
OBJECTIVES:
Primary
- Determine whether peak standardized uptake value (SUV) for fludeoxyglucose F 18 positron emission tomography (FDG-PET) shortly after definitive chemoradiotherapy is predictive of long-term survival of patients with inoperable stage IIB or III non-small cell lung cancer.
Secondary
- Determine whether max SUV for FDG-PET shortly after definitive chemoradiotherapy is predictive of long-term survival in these patients.
- Determine whether post-treatment imaging using peak and max SUV for FDG-PET shortly after definitive chemoradiotherapy is predictive of local disease control in these patients.
- Determine whether pre-treatment imaging using these techniques is predictive of long-term survival and local disease control in these patients.
- Correlate, if possible, Ki-67 expression with overall survival of patients assessed with these imaging techniques.
研究设计
- 研究类型
- Interventional
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Relationship of survival to post-treatment peak standardized uptake value (SUV) as determined by the imaging institution
次要结局
- Relationship of survival to post-treatment max SUV as determined by the imaging institute
- Relationship of local control to post-treatment peak and max SUV as determined by the imaging institution
- Relationship of survival and of local control to pre-treatment peak and max SUV as determined by the imaging institution
- Reliability between peak and max SUV measurements both pre- and post-treatment
- Proportion of participants who are either upstaged or downstaged by positron emission tomography scan
- Reliability between PET scan-defined response to therapy measurements
- Correlation of Ki-67 expression with peak and max pre-treatment SUV
- Association between Ki-67 expression and overall survival at 2 years
研究者
研究点 (98)
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