Examining Techniques on Adenoma Miss Rate in Proximal Colon
- Conditions
- Colorectal AdenomaColorectal Polyp
- Interventions
- Procedure: RetroflexionProcedure: Re-examination
- Registration Number
- NCT03355443
- Lead Sponsor
- Changhai Hospital
- Brief Summary
The primary aim of this study is
- to explore the usefulness of re-examination and retroflexion on adenoma miss rate (AMR) in the proximal colon.
Other aims include to explore the data below when re-examination or retroflexion is used.
* Adenoma detection rate, ADR
* Polyp miss rate, PMR
* Polyp detection rate, PDR
* Withdrawal time, WT
- Detailed Description
AMR = number of adenomas missing during the first examination/ total number of adenomas in both examinations = number of adenomas detected only in the second examination/(number of adenomas detected during the first examination + number of adenomas detected only in the second examination)
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 600
- Patients between 45 and 80 years who undergo colonoscopy examination for screening, and who receive primary screening and get positive result
- Pregnant female patients
- Patients received colonoscopy in the past 5 years
- Patients who have history of colorectal cancer, colorectal polyposis, inflammatory bowel disease or heredity colorectal neoplasm syndrome such as familiar adenomatous polyposis, Lynch Syndrome and so on
- Patients who had previous abdominal surgery
- Patients who are known to have colonic stricture or obstructing tumor from the results of radiography (X ray, CT scan or barium enema)
- Patients who are presenting acute surgical conditions such as severe colitis, megacolon and active gastrointestinal bleeding
- Patients who have inadequate bowel preparation
- Patients who reject to participate in this study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Retroflexion Group Retroflexion Routine intubation is performed. After cecal intubation, the cecum and ascending colon is examined with colonoscope tip in forward direction for the first time. Re-intubation is performed after the first examination of the cecum and ascending colon, and then this region of the large bowel is re-examined with the colonoscope tip in reverse direction (retroflexion fashion). After that, the rest of the colon is examined in routine method. Re-examination Group Re-examination Routine intubation is performed. After cecal intubation, the cecum and ascending colon is examined with colonoscope tip in forward direction for the first time. Re-intubation is performed after the first examination of the cecum and ascending colon, and then this region of the large bowel is re-examined in the same fashion. After that, the rest of the colon is examined in routine method.
- Primary Outcome Measures
Name Time Method Adenoma miss rate in the proximal colon (AMR) At the end of the procedure, up to 1 hour AMR refers to the rate of adenoma missing, calculated as the proportion of adenomas which are missing in the first examination. AMR in the proximal colon is calculated with only the proximal colon concerned.
- Secondary Outcome Measures
Name Time Method Adenoma Detection Rate in the proximal colon (ADR) At the end of the procedure, up to 1 hour ADR refers to the rate of adenoma detection, calculated as the proportion of subjects with at least one adenoma. ADR in the proximal colon is calculated with only the proximal colon concerned.
Trial Locations
- Locations (3)
the Sixth affiliated Hospital of Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China
Zhongshan Hospital affiliated to Fudan University
🇨🇳Shanghai, China
Tianjin Renmin Hospital
🇨🇳Tianjin, China