Benefits of vitamin thiamine, vitamin C,vitamin B12 in children with severe infection - RCT
Not Applicable
- Conditions
- Health Condition 1: B95-B97- Bacterial and viral infectious agents
- Registration Number
- CTRI/2020/11/028825
- Lead Sponsor
- Rainbow childrens hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All Cases of Severe sepsis and septic shock will be categorised to study grup and control group. Study group will receive inj Thiamine, vitamin C, Vitamin B12 along with standard treatment as per PICU protocol. Control group would receive only standard treatment as per PICU protocol
Exclusion Criteria
KNOWN CASE OF VITAMIN C,THIAMINE, B12 Deficiency
cases of dilated cardiomyopathy
INBORN ERROR OF METABOLISM
RENAL STONES
ALLERGY TO VITAMIN C, THIAMINE, B12
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality BenefitsTimepoint: Mortality Benefits
- Secondary Outcome Measures
Name Time Method actate levels, <br/ ><br>SOFA Scores <br/ ><br>VIS Scores, <br/ ><br>Length of PICU stay and hospital stayTimepoint: 5 Days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie thiamine, vitamin C, and B12 metabolic resuscitation in pediatric severe sepsis?
How does thiamine-vitamin C-B12 combination compare to standard-of-care therapies for bacterial/viral sepsis in children?
Which biomarkers correlate with clinical response to thiamine, vitamin C, and B12 in CTRI/2020/11/028825 pediatric sepsis trial?
What are the safety profiles and adverse event management strategies for high-dose thiamine, vitamin C, and B12 in septic pediatric patients?
Are there alternative vitamin combinations or adjunct therapies being investigated for metabolic resuscitation in B95-B97 pediatric infections?