Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

Not Applicable

Completed

• Conditions: Blood Cancer; Blood and Marrow Transplant (BMT)

• Registration Number: NCT00186225
• Lead Sponsor: Stanford University

Brief Summary

To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Detailed Description

Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

Study Timeline

• Study Start: 1989-11
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-16
• Primary Completion: 2007-06
• Study Completion: 2010-05
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-07
• Last Update Posted: 2020-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• acute leukemia

• chronic leukemia
• lymphoblastic lymphoma
• MDS
• MPS

Exclusion Criteria

• organ dysfunction

• HIV positive

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

Secondary Outcome Measures

Name	Time	Method
Overall Survival
Event Free Survival

Trial Locations

Locations (1)

Stanford University School of Medicine; 🇺🇸 Stanford, California, United States