Gastric Emptying of Rice With Different Starch Properties

Not Applicable

Completed

• Conditions: Appetitive Behavior
• Interventions: Other: White rice, slow; Other: White rice, resistant; Other: Brown rice, high amylose; Other: White rice, high amylose; Other: Brown rice, low amylose; Other: White rice, low amylose; Other: Fructooligosaccharide (FOS)

• Registration Number: NCT03035981
• Lead Sponsor: Purdue University

Brief Summary

Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

Detailed Description

Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

Study Timeline

• Study Start: 2014-08
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2017-01
• Study First Submitted: 2017-01-26
• Study First Submitted QC: 2017-01-26
• Last Update Submitted: 2017-01-26
• Study First Posted: 2017-01-30
• Last Update Posted: 2017-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

Exclusion Criteria

• Under any medication
• History of any gastrointestinal disease or surgery
• Diabetes
• Smoker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
White rice, slow	White rice, slow	Cooked white rice with slow digesting starch
White rice, resistant	White rice, resistant	Cooked white rice with resistant starch
Brown rice, high amylose	Brown rice, high amylose	Cooked brown rice with high amylose content
White rice, high amylose	White rice, high amylose	Cooked white rice with high amylose content
Brown rice, low amylose	Brown rice, low amylose	Cooked brown rice with low amylose content
White rice, low amylose	White rice, low amylose	Cooked white rice with low amylose content
Fructooligosaccharide (FOS)	Fructooligosaccharide (FOS)	Fermentable carbohydrate solution

Primary Outcome Measures

Name	Time	Method
Appetitive response	Acute study, 4 hours after consumption of test food	Fullness and hunger questionnaire was given at various time points after consumption of test foods
Gastric emptying	Acute study, 4 hours after consumption of test food	Breath test was performed using 13C-octanoic acid mixed into test meals

Secondary Outcome Measures

Name	Time	Method
Breath hydrogen	Acute study, 4 hours after consumption of test food	Hydrogen breath test was performed following ingestion of test meals