Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Not Applicable

Completed

• Conditions: CPAP; Hypoxic Ventilatory Response; Rocuronium; Neuromuscular Blockade; OSA
• Interventions: Drug: Rocuronium

• Registration Number: NCT01672606
• Lead Sponsor: Malin Jonsson Fagerlund

Brief Summary

This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2012-06-01
• Study First Submitted QC: 2012-08-22
• Study First Posted: 2012-08-27
• Status Verified: 2016-02
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Last Update Submitted: 2016-02-26
• Last Update Posted: 2016-02-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI <35.

Exclusion Criteria

• If they don´t fit the inclusion criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Rocuronium	Rocuronium	Intravenous infusion of rocuronium with the goal of TOF 0.70 and \>0.90

Primary Outcome Measures

Name	Time	Method
Hypoxic ventilatory response	At baseline, with CPAP, at TOF 0.70 and at TOF >0.90. At diagnosis and after 3 month of CPAP treatment at home

Secondary Outcome Measures

Name	Time	Method
Hypercarbic ventilatory response	At diagnosis and after 3 month of CPAP treatment at home
Hypoxic ventilatory response	At diagnosis and after 3 month of CPAP treatment at home
Hypoxic ventilatory response during acute CPAP treatment	At diagnosis and after 3 month of CPAP treatment
Hypercarbic ventilatory response during acute CPAP treatment	At diagnosis and after 3 month CPAP treatment at home
Upper airway obstruction	At TOF 0.70 and TOF >0.90. At diagnosis and after 3 month CPAP treatment.

Trial Locations

Locations (1)

Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital; 🇸🇪 Stockholm, Sweden