Effects of omega-3 fatty acids on fatty liver and insulin sensitivity.
- Conditions
- non-alcoholic fatty liver disease (NAFLD)hepatic steatosisinsulin sensitivitymorbid obesityomega-3 fatty acids
- Registration Number
- NL-OMON26624
- Lead Sponsor
- Academic Medical Center, Amsterdam, The Netherlands.
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. MRS suggesting NAFLD;
2. 18-65 years of age;
Exclusion Criteria
1. Use of lipid lowering drugs (i.e., statins and fibrate drugs);
2. Any medication except anti-hypertensives, levothyroxine, OAC;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To assess the effects of omega-3 fatty acids on hepatic steatosis;<br /><br>2. To assess the effects of omega-3 fatty acids on hepatic and peripheral insulin resistance.
- Secondary Outcome Measures
Name Time Method 1. Liver volume;<br /><br>2. Fatty acids in the basal state and during hyperinsulinemia;<br /><br>3. Plasma lipid profile;<br /><br>4. Hepatic lipid profile;<br /><br>5. Resting energy expenditure (REE);<br /><br>6. Differences in expression profiles in liver tissue;<br /><br>7. Histological classification of hepatic steatosis;<br /><br>8. Changes in circulating inflammatory proteins.