Early versus Late switch over of Antiepileptic drugs from Intravenous to the Oral route in children aged 1 month to 18 years with seizures: Single blinded, Randomized controlled trial - ELAIO trial

All India Institute of Medical Sciences0 个研究点目标入组 112 人开始时间: 待定最近更新: 2024年1月22日

试验速览

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•1. Children aged between 1 month-18 years, presented to paediatric emergency/ward/OPD with at least one episode of clinical seizure
•2. At least one episode of seizure during the hospital stay
•3. Requires at least one dose of intravenous antiepileptic drug
•4. Able to receive and tolerate medications via oral or gastric feeding tube route
•5. Able to receive and tolerate a diet or enteral feeding (via gastric feeding tube)

•1. Clinical suspicion of Non Convulsive Status Epilepticus (Salzburg criteria), but EEG has not ruled out NCSE
•2. Refractory nausea, vomiting and/or diarrhea in the last24 hours
•3. Use of a feeding tube that terminates distal to the stomach (e.g. jejunal tube)
•4. Active gastrointestinal bleeding
•5. Any other physical condition, likely to increase risk of aspiration on oral ingestion, impair absorption, first-pass metabolism or bioavailability
•6. Caregiver not providing informed consent.

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