LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START IN IVF

Not Applicable

Not yet recruiting

• Conditions: IVF
• Interventions: Other: Ovarian Stimulation Start

• Registration Number: NCT06551376
• Lead Sponsor: Clinia de fertilización Asistida en el Hospital ABC

Brief Summary

To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Detailed Description

Objective To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Design Multicentric prospective non-randomized study

Setting Two university-affiliated private assisted reproduction centers.

Patient(s) Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled. Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria.

Intervention(s) Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses; similarly, twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day.

Main Outcome Measure(s) Primary outcome: number of mature oocytes retrieved. Secondary outcomes: fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate, and clinical pregnancy outcomes from FET cycles.

Study Timeline

• Status Verified: 2024-08
• Study First Submitted: 2024-08-09
• Study First Submitted QC: 2024-08-09
• Last Update Submitted: 2024-08-09
• Study First Posted: 2024-08-13
• Last Update Posted: 2024-08-13
• Study Start: 2024-09-01
• Primary Completion: 2025-01-31
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled

Exclusion Criteria

• Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Late Luteal Phase ovarian stimulation	Ovarian Stimulation Start	Twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day.
Early Follicular Phase ovarian stimulation	Ovarian Stimulation Start	Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses

Primary Outcome Measures

Name	Time	Method
mature oocytes retrieved	At retrieval

Secondary Outcome Measures

Name	Time	Method
fertilization rate	24 hours after retrieval
viable embryo rate per oocyte retrieved	5 days after retrieval
cancellation rate	14 days after cycle start