To Study Haemodynamic Effects Of Preoperative Single Bolus Of Dexmedetomidine In Elective Laparoscopic Surgeries

Phase 1/2

Completed

Conditions: Acute appendicitis with generalized peritonitis, (2) ICD-10 Condition: K800||Calculus of gallbladder with acutecholecystitis,

Registration Number: CTRI/2021/07/034890

Lead Sponsor: Department of Anaesthesia

Brief Summary: Before induction patients will recieve IV Dexmedetomifine at 1 micrograms/ kg in 50 ml of 0.9% NS or 50 ml of 0.9% NS, and a balanced general anaesthesia technique will be adopted for all patients. Haemodynamic parameters will be assessed before the start of infusion, 10 mins after the start of infusion, immediately after induction, after laryngoscopy, intubation at 1, 3, 5 mins. Data will be collected from the time of pneumoperitoneum, after extubation. Postop pain score will be assessed and the time to first rescue analgesic requirement and total amount of analgesic drugs required during first 24 hours post operatively will be noted down.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 60

Inclusion Criteria

ASA grade I and II patients undergoing elective laparoscopic surgeries under general anaesthesia Haemodynamically stable patietns availability of informed consents.

Exclusion Criteria

Patient refusal ASA III and more age below 18 and above 60 patients posted for emergency surgeries patients who are on drugs that can influence haemodynamic and autonomic functions predictable difficult airway or difficult intubation pre existing heart condition pregnancy and breast feeing women co-existing illness like respiratory, renal or cerebral diseases surgeries converted to open surgeries known allregy to any of the drugs used in the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to study the effects of dexmedetomidine on hemodynamic parameters during perioperative periods in patients undergoing elective laparoscopic surgeries	Every 5 minutes post induction

Secondary Outcome Measures

Name	Time	Method
to study post operative sedation score using ramsay sedation scale	6 hours
To study the time taken for the first analgesic requirement.	12 hours
To study the side effects of Dexmedetomidine and their management	Every 5 minutes post induction

Trial Locations

Locations (1): Operation Theatre
🇮🇳
Pune, MAHARASHTRA, India
Operation Theatre
🇮🇳Pune, MAHARASHTRA, India
Fathima
Principal investigator
9746290791
drfthma@gmail.com