Effect of Potato Fiber on Appetite and Fecal Fat Excretion

Not Applicable

Completed

• Conditions: Fecal Fat Increased; Obesity; Appetite
• Interventions: Dietary Supplement: FiberBind; Dietary Supplement: Placebo; Dietary Supplement: RG-I fiber

• Registration Number: NCT02957318
• Lead Sponsor: University of Copenhagen

Brief Summary

Results have indicated that some dietary fibers increase fecal fat excretion and particularly viscous fibers suppress appetite sensation and reduce energy intake. Both these effects may contribute to body weight management.

Aim: The aim of the study is to investigate the potential of 3-weeks daily intake of potato pulp (FiberBind), rhamnogalacturonan I isolated potato fiber (RG-I) vs. a low-fiber control (placebo) on satiety and fecal fat excretion in healthy adults. Furthermore, a number of secondary endpoints are investigated.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2016-11-01
• Study First Submitted QC: 2016-11-04
• Study First Posted: 2016-11-06
• Primary Completion: 2017-03-31
• Study Completion: 2017-03-31
• Status Verified: 2017-05
• Last Update Submitted: 2017-09-12
• Last Update Posted: 2017-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 18

Inclusion Criteria

• Healthy Men
• BMI between 18.5 and 27.0 kg/m2
• Age 20-40 years

Exclusion Criteria

• Intake of potatoes with main meals more frequent than 4 times per week
• Chronic diseases (known diabetes, cardiovascular disease, irritable bowels disease, colitis ulcerosa, crohn disease, or other chronic diseases which could affect the results of the present study)
• Gluten allergy
• Use of daily prescription medicine (mild analgesics are allowed)
• Use of lipid-lowering agents (e.g. Becel, HUSK)
• Use of food supplements of relevance to the study (such as pre- and probiotics)
• Irregular intake of vitamin /mineral supplements (two weeks prior to and during the entire study period)
• Smoking
• Elite athletes (>10 hours of strenuous physical activity per week)
• Blood donation (<1 month before study commencement and during study period)
• Participation in other clinical studies (<1 month before study commencement and during study period)
• Inability (physically or psychologically) to comply with the procedures required by the protocol judged by the Investigator

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
FiberBind	FiberBind	-
Placebo	Placebo	-
RG-I fiber	RG-I fiber	-

Primary Outcome Measures

Name	Time	Method
Subjective appetite sensations	Assessed on 3-hour meal test on last day of the 21-day intervention periods	Assessed by visual analogue scales (VAS)
Fecal fat excretion	Based on total feces collection the last 3 days of the 21-day intervention periods

Secondary Outcome Measures

Name	Time	Method
Gut microbiota	Measured in a fresh feces sample from day 19-21 of the intervention periods
Gastrointestinal symptoms (questionnaire)	on day 1, 7, 14 and 22 of the 21-day intervention periods
Blood pressure	up to 21-day intervention periods
Breath hydrogen	up to 21-day intervention periods
Body weight	up to 21-day intervention periods
Ad libitum energy intake	Assessed 3 hours after intake of the test meal on last day of the 21-day intervention periods
Fecal energy excretion	Measured based on total feces collection the last 3 days of the 21-day intervention periods
Insulin and glucose	Measured before and after the 21-day intervention periods, and every 30 minutes during the 3-hour meal test on last day of the 21-week intervention periods
Gut permeability marker	Measured before and after the 21-day intervention periods
Blood lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides)	Measured before and after the 21-day intervention periods
Gastric emptying rate (w. paracetamol)	Measured every 30 minutes during the 3-hour meal test on last day of the 21-day intervention periods

Trial Locations

Locations (1)

University of Copenhagen, Department of Nutrition, Exercise and Sports; 🇩🇰 Copenhagen, Denmark