Comparaison Between MRI Alone or Combined With Positron Emission Tomography for Brain Metastasis Diagnosis

Completed

• Conditions: Brain Metastases, Adult

• Registration Number: NCT05095766
• Lead Sponsor: Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-15
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Male or female over 18 years of age;<br><br> - Having undergone gamma knife radiosurgery for brain metastasis;<br><br> - Presenting for a first MRI follow-up (Cohort C1);<br><br> - Presence of one or more brain metastases with increased enhancement on follow-up MRI<br> (Cohort C2.1 and C2.2); A participant recruited for Cohort C1 could be recruited for<br> follow-up in Cohort C2.1 or C2.2 if the MRI result is ambiguous.<br><br>Exclusion Criteria:<br><br> - Pregnancy or breastfeeding;<br><br> - Other condition that may influence the imaging result;<br><br> - Renal impairment (<30 mL/min/1.73 m2). This threshold is consistent with recent RAC<br> recommendations; Note: For participants with intermediate renal clearance (30-60<br> mL/min/1.73 m2), the total gadobutrol dose injected is set at the manufacturer's<br> recommended clinical dose. For patients with renal clearance greater than 60<br> mL/min/1.73 m2, a dose of 1.5x the normal dose is used. These dose values have been<br> approved by Dr. Chénard and are consistent with the RAC recommendations.<br><br> - Inability to maintain supine position for the required duration (variable, depending<br> on the sequence);<br><br> - Patients who have previously received full brain irradiation;<br><br> - Patients who are claustrophobic and cannot tolerate insertion into the MRI scanner;

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of novel MRI method with current MRI exam method;Comparison of DCE-MRI method with FET PET