sing advanced MRI sequence to distinguish between cancer and radiation induced damage in treated brain tumors like Glioma
Not Applicable
- Conditions
- Health Condition 1: C71- Malignant neoplasm of brain
- Registration Number
- CTRI/2024/03/064109
- Lead Sponsor
- Dr ARPITA SAH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with histologically proven higher grade gliomas who underwent treatment (chemotherapy, radiotherapy or both) and having suspicion for tumor recurrence or radiation necrosis.
Exclusion Criteria
1.Patients with non-glial tumors on histology.
2.Patients who do not have tissue diagnosis or are lost on imaging follow up.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To assess the utility of Arterial Spin Labeling (ASL) in brain tumor protocol for distinguishing tumor recurrence from radiation necrosis in treated cases of grade 3 and 4 gliomas.Timepoint: Project time is 3 years.
- Secondary Outcome Measures
Name Time Method 1.To compare findings of perfusion i.e.Arterial Spin Labeling (ASL) and Dynamic Susceptibility Contrast (DSC) MRI. <br/ ><br>2.Quantitative analysis of ASL, DSC findings. <br/ ><br>3.Qualitative analysis of ASL and DSC perfusion maps. <br/ ><br>4.To assess anyaltered signal by other MR sequences – T1W, T2W, T1 FLAIR, Post contrast T1, Post contrast T2 FLAIR, Diffusion weighted imaging, Spectroscopy. <br/ ><br>5.Comparison of MRI results with amino acids.Timepoint: Project time is 3 years.