Comparison of two different medications for treating low blood pressure after spinal anesthesia for cesarean sectio
- Conditions
- Pregnancyspinal anesthesia for cesarean deliveryAnaesthesiology - Other anaesthesiologyReproductive Health and Childbirth - Childbirth and postnatal care
- Registration Number
- ACTRN12618000244202
- Lead Sponsor
- Women's Hospital, Hamad Medical Corporation;
- Brief Summary
In summary, we determined the minimal infusion rates (median effective rate, ED50) of phenylephrine and noradrenaline in prevention of hypotension after spinal anesthesia for caesarean delivery and found that noradrenaline is more potent than phenylephrine by a factor of 12.6 for equivalent maternal blood pressure control. At the minimal infusion rates, noradrenaline does not provide greater cardiac output.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 60
The study population will consist of patients aged 18-45 years, ASA II, BMI 25-40kg/m2, height 150–180 cm, and who have a normal singleton pregnancy beyond 36 weeks gestation, undergoing elective cesarean delivery under spinal anesthesia.
onset of labor, patients with gestational hypertension, history of diabetes, cardiovascular and cerebrovascular problems, fetal abnormalities and patients taking monoamine oxidase inhibitors or tricyclic antidepressants. Moreover, all patients with baseline arterial blood pressure >140/90, or heart rate <60 or >110 beats per minute will be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method