Gingival tissue augmentation using hyaluronic acid with or without micro-needling

Phase 4

Completed

• Conditions: Disorder of gingiva and edentulousalveolar ridge, unspecified,

• Registration Number: CTRI/2022/09/045601
• Lead Sponsor: KVG DENTAL COLLEGE AND HOSPITAL

Brief Summary

This study is a randomized, outcome assessor blinded, parallel group, single center trial comparing the efficacy of 0.1 ml of injectable hyaluronic acid filler on one side, injected just below the mucogingival junction  and 0.1 ml of injectable hyaluronic acid filler with micro-needling using 30 gauge lancet needle which is inserted until hard tissue is felt on the keratinized gingiva from mesial side of the central incisor to the distal part of canine on other side after initial scaling 1 week prior to the commencement of the interventional study in patient with thin gingival biotype with <0.8mm of gingival thickness. The primary outcome is to assess the thickness of the keratinized gingiva after 15 days, 1 month, 2 month and 3 months after the treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-19
• Study Completion: 2023-03-31
• Last Update Posted: 2025-11-03

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Systemically healthy patients.
• Mandibular anterior teeth <0.8 mm gingival thickness.
• Full mouth plaque index and BOP score of <15 % Gingival index < 1 % score.

Exclusion Criteria

• patient with known systemic disease.
• Patient underwent treatment with antibiotics within last three months.
• Patient who underwent treatment with anti-inflammatory drug within the last three months.
• Patient undergoing orthodontic treatment.
• Patient who underwent periodontal therapy within the last six months.
• Pregnancy or use of oral contraceptive.
• Patient using blood thinners.
• Patient on medications which will lead to gingival enlargement.
• Malocclusion.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To increase the gingival thickness	Baseline | 15 days | 1 month | 2 month | 3 month

Trial Locations

Locations (1)

KVG dental college and hospital; 🇮🇳 Kannada, KARNATAKA, India

KVG dental college and hospital

🇮🇳Kannada, KARNATAKA, India

Dr Apoorva G

Principal investigator

8792246513

dr.apoorva135@gmail.com