To compare the effect of esmolol and lidocaine on middle cerebral artery during emergence from anaesthesia

Not yet recruiting

• Conditions: Calculus of gallbladder and bile duct without cholecystitis, (2) ICD-10 Condition: H701||Chronic mastoiditis, (3) ICD-10 Condition: G55||Nerve root and plexus compressionsin diseases classified elsewhere, (4) ICD-10 Condition: K469||Unspecified abdominal hernia without obstruction or gangrene,

• Registration Number: CTRI/2023/12/060488
• Lead Sponsor: Department of Anaesthesiology and Critical Care Jawaharlal Nehru Medical college AMU Aligarh

Brief Summary

Tracheal intubation and extubation are critical steps during anaesthetic care where cardiovascular and respiratory decompensation can occur such as tachycardia, hypertension, arrythmias, myocardial ischaemia, bradycardia or laryngospasm.

These potentially fatal complications related to extubation result from stimulation of the larynx, trachea and bronchi which increase the release of catecholamine concentration.

Cerebral hyperaemia occur during extubation which is demonstrated by concomitant increase in cerebral blood flow velocity(CBFV).

A possible mechanism of hyperaemia and increasd CBFV is the sympathetic stimulation associated with emergence.

Pharmacological strategies such as local anaesthesia, N-Methyl - D -aspartate(NMDA) antagonist , alpha -2- agonist and beta- blocker can significantly blunt the sympathetic overactivity and reduce the rate of serious outcome relate to emergence.



We hypothesize that blunting the sympathetic overactivity will decrease CBFV and cerebral hyperaemia at emergence from anaesthesia

Therefore, we planned this prospective, randomised, double blind, placebo controlled study to comparatively analyse the effect of single dose esmolol and lidocaine on MCA velocity during emergence from anaesthesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-12
• Study Start: 2023-12-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Physical status of ASA I & II 2) Mallampati score class I & II.

Exclusion Criteria

1. Physical status of ASA III & IV 2) Those with significant systemic disorder 3) Those with uncontrolled hypertension and cerebrovascular disease 4) Those with co-morbid disease 5) Allergy to local anaesthetic and those on beta- blocker therapy Pregnant female.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of esmolol and lidocaine on Middle cerebral artery velocity during emergence from anaesthesia	1) T0- During anaesthesia | 2) T1- before administration of drugs (when train of four response is more than 90%) | 3) T2- After two minute of administration of drug | 4) T3- After three minutes of extubation

Secondary Outcome Measures

Name	Time	Method
1. To analyse and compare the effect of esmolol and lidocaine on hemodynamic parameters e.g systolic blood pressure(SBP), heart rate(HR) during emergence from anaesthesia	2. To correlate the change in hemodynamic parameters (SBP, HR) with MCA velocity during emergence from anaesthesia

Trial Locations

Locations (1)

Jawaharlal Nehru Medical College, AMU, Aligarh; 🇮🇳 Aligarh, UTTAR PRADESH, India

Jawaharlal Nehru Medical College, AMU, Aligarh

🇮🇳Aligarh, UTTAR PRADESH, India

Dr Lhingneilam Haokip

Principal investigator

8787312917

lhingneilamhaokip61@gmail.co.in