Intracranial venous blood flow in idiopapathic and secondary intracranial hypertension – hemodynamic impact of normalization of cerebro-spinal fluid pressure
- Conditions
- G93.2G96.0Benign intracranial hypertensionCerebrospinal fluid leak
- Registration Number
- DRKS00013741
- Lead Sponsor
- eurologische Klinik, Universitätsklinikum Freiburg
- Brief Summary
We demonstrated the interaction of cerebrospinal fluid (CSF) pressure, venous volumetry, venous hemodynamics and optic nerve sheath diameter (ONSD) using multiparametric brain MRI. Closure of CSF leaks in spontaneous intracranial hypotension patients resulted in symptoms suggestive of increased intracranial pressure and caused a subsequent decrease of intracranial venous volume and of blood flow within the superior sagittal sinus while ONSD increased. In contrast, blood flow parameters from 4D flow MRI did not discriminate idiopathic intracranial hypertension, spontaneous intracranial hypotension and controls as hemodynamics at baseline overlapped at most vessel cross-sections between groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 31
age > 18 years; clinical picture of an idiopathic intracranial hypertension (IIH) or of a cerebrospinal fluid (CSF) leakage syndrome and/or elevated or lowered CSF pressure or clinical or sonographic suspicion of IIH or optic nerve dis edema.
Lack of consent, bad clinical state, contraindications against lumbar puncture or MRI examination at 3 Tesla, astigmatism, history of optic neuritis, presbyopsia.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To improve understanding of pathophysiology of IIH and to improve diagnostic and treatment in future patients
- Secondary Outcome Measures
Name Time Method not applicable