IRCT20211112053042N2
Recruiting
Phase 2
Evaluation of efficacy and safety of morphine through nebulizer mask in the treatment of acute respiratory distress due to Covid-19 in adult patients
Karaj University of Medical Sciences0 sites60 target enrollmentTBD
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Karaj University of Medical Sciences
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 80\-18 years
- •Patients with a definitive diagnosis of Covid\-19 based on PCR test within 48 hours after hospitalization
- •Acute moderate respiratory distress syndrome with PaO2 / FiO2 \<200 based on Berlin criteria (Force et al., 2012\)
- •Patients with severe dyspnea
- •Patients in the end\-stages of the disease
- •Lack of proper treatment
- •Patients with consent to participate in the project
Exclusion Criteria
- •Patients with high suspicion / diagnosis of heart failure and unstable angina
- •Existence of severe shock with hemodynamic instability despite increased vascular pressure
- •Severe / undiagnosed lung infection for other reasons (chronic obstructive pulmonary disease, pulmonary fibrosis, lung cancer, bacterial pneumonia ...)
- •Diagnosis of pulmonary hemorrhage
- •Pregnancy / breastfeeding
- •An important cause other than acute respiratory distress for respiratory failure
- •Requires ECMO during the study period
- •He/she is expected to be transferred to another hospital within 72 hours
- •Known allergies to morphine
- •Sensitivity or contraindication to exogenous and endogenous opioids
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Effectiveness and safety of morphine therapy as palliative care in advanced heart failure patients -multicenter prospective observational studyHeart failureJPRN-UMIN000041669ational Hospital Organization Kyoto Medical Center28
Completed
Not Applicable
Efficacy and complications of morphine suppositoryacute postoperative pain.IRCT2012103111338N1Ardabil University of Medical Sciences75
Recruiting
Phase 3
Effect of morphin in prognose of Anterior MIAcute Anterior ST Elevatiom Myocardial Infarction.ST elevation (STEMI) myocardial infarction of anterior wallI21.0IRCT20230102057018N1Research Assistant of Tabriz University of Medical Sciences200
Active, not recruiting
Not Applicable
Clinical trial to assess the efficacy and safety of different analgesic strategies in the treatment of pain in surgery of piles.The combined use with local anesthetics may allow for a reduction in the dose of the latter, without impairment of intraoperatory anesthesia, improving the early mobility of patients and minimizing the adverse effects.MedDRA version: 14.1Level: LLTClassification code 10036236Term: Postoperative pain reliefSystem Organ Class: 10042613 - Surgical and medical proceduresTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]EUCTR2012-000110-11-ESFundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias
Not yet recruiting
Phase 4
To asses the effect of spinal morphine on inflammatory markers and clinical outcome in patients undergoing open heart surgeryHealth Condition 1: I39- Endocarditis and heart valve disorders in diseases classified elsewhereHealth Condition 2: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classifiedCTRI/2023/07/055338All India Institute of Medical sciences