The effect of morphine with nebulizer mask in the treatment of acute respiratory distress in adult patients with Covid-19

Phase 2

Recruiting

Conditions: Acute respiratory distress caused by Covid-19.
Coronavirus as the cause of diseases classified to other chapters
B97.2

Registration Number: IRCT20211112053042N2

Lead Sponsor: Karaj University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Age 80-18 years
Patients with a definitive diagnosis of Covid-19 based on PCR test within 48 hours after hospitalization
Acute moderate respiratory distress syndrome with PaO2 / FiO2 <200 based on Berlin criteria (Force et al., 2012)
Patients with severe dyspnea
Patients in the end-stages of the disease
Lack of proper treatment
Patients with consent to participate in the project

Exclusion Criteria

Patients with high suspicion / diagnosis of heart failure and unstable angina
Existence of severe shock with hemodynamic instability despite increased vascular pressure
Severe / undiagnosed lung infection for other reasons (chronic obstructive pulmonary disease, pulmonary fibrosis, lung cancer, bacterial pneumonia ...)
Diagnosis of pulmonary hemorrhage
Pregnancy / breastfeeding
An important cause other than acute respiratory distress for respiratory failure
Requires ECMO during the study period
He/she is expected to be transferred to another hospital within 72 hours
Known allergies to morphine
Sensitivity or contraindication to exogenous and endogenous opioids
Obesity (BMI>35 kg/m2 )
Patients with dissatisfaction with participating in the project

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality rate. Timepoint: During hospitalization. Method of measurement: Based on the patient's record.

Secondary Outcome Measures

Name	Time	Method
Oxygen saturation level. Timepoint: Morphine dose before titration, 2 hours after first titration, 2 hours after second titration, 2 hours after third titration, 2 hours after effective drug titration, 12 hours after effective drug titration, 24 hours after effective drug titration. Method of measurement: Pulse oximetry.