To asses the effect of spinal morphine on inflammatory markers and clinical outcome in patients undergoing open heart surgery
Phase 4
- Conditions
- Health Condition 1: I39- Endocarditis and heart valve disorders in diseases classified elsewhereHealth Condition 2: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified
- Registration Number
- CTRI/2023/07/055338
- Lead Sponsor
- All India Institute of Medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of either sex , aged 18 and above belonging to American society of anaesthesiologists (ASA) physical status II-IV and scheduled for valve replacement surgery under cardiopulmonary by pass will be included
Exclusion Criteria
Emergency surgery ,combined CABG and valvular surgery , prior cardiac surgery left ventricular fraction LVEF < 0.5 , prospective mechanical ventilation intra aortic balloon pump ,chronic liver disease and patients having any contraindication for intrathecal injection will be excluded
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the level of IL-6 between the groups at o & 24 hours after surgeryTimepoint: To compare the level of IL-6 between the groups at o & 24 hours after surgery
- Secondary Outcome Measures
Name Time Method 1 To compare the platelet to lymphocyte ratio (PLR) between the groups <br/ ><br>2 To compare the neutrophil to lymphocyte ratio (NLR) between the groups <br/ ><br>3 To compare the CRP between the groups <br/ ><br>4 To compare the need of inotropic support between the groups <br/ ><br>5 Time to extubation between the groups <br/ ><br>6 To compare VAS scores between the groups <br/ ><br>7 Need of analgesia in 24 hours between the groups <br/ ><br>8 To compare length of ICU stay between the groups <br/ ><br>9 To compare all cause mortality between the groupsTimepoint: To compare the outcomes between the groups at 0 & 24 hours after the surgery