The Impact of Remimazolam and Propofol on the Left Ventricular Systolic Performance During Anesthesia-induction for Non-cardiac Surgery: a Speckle Tracking Analysis of the Left Ventricular Strain Using Transthoracic Echocardiography
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- the averaged longitudinal strain of the left ventricle (%)
研究概览
简要总结
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery.
LV-GLS is analyzed by using speckle tracking technique of transthoracic echocardiography.
详细描述
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery (n=40).
Remimazolam or propofol is randomly administered for anesthesia induction (Group-R and Group-P, respectively) The changes of LV-GLS are analyzed by using using speckle tracking technique. For this study, 2-dimensional of transthoracic echocardiography LV images (apical 2-chamber, 3-chamber, and 4-chamber views) are recorded and stored before administration of remimazolam/propofol (T0), 2 minutes after the administration (T2), 4 minutes after the administration (T4), and 6 minutes after the administration (T6).
After the completion of the study, LV-GLS values at T0, T2, T4 and T6 are determined by the off-line analyses of the recorded and stored 2D-images.
For the off-line determination of LV-GLS, an automated software of speckle-tracking technique (Qapp Autostrain-LV™, Philips) is employed.
The primary measure:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •left ventricular ejection fraction> 50%
- •no left ventricular regional wall motion abnormality
排除标准
- •atrial fibrillation
- •unfavorable airway
- •hypotension requiring inotropic support
研究组 & 干预措施
Remimazolam
remimazolam infusion
干预措施: Remimazolam infusion (Drug)
Propofol
propofol infusion
干预措施: Propofol infusion (Drug)
结局指标
主要结局
the averaged longitudinal strain of the left ventricle (%)
时间窗: 2.5 minutes
inter-group comparisons of the lowest values of the longitudinal strains of the left ventricle in the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
次要结局
- the longitudinal strain of the left ventricle in apical 2 chamber view (%)(2.5 minutes)
- the longitudinal strain of the left ventricle in apical 4 chamber view (%)(2.5 minutes)
- the election fraction of the left ventricle(2.5 minutes)
- the longitudinal strain of the left ventricle in apical long-axis view (%)(2.5 minutes)
研究者
Tae-Yop Kim, MD PhD
Professor, Department of Anesthesiology
Konkuk University Medical Center