Effectiveness Of HDtDCS In Cognitive And Negative Symptoms Of Schizophrenia measured Using fMRI
- Conditions
- Health Condition 1: F20- Schizophrenia
- Registration Number
- CTRI/2021/07/034759
- Lead Sponsor
- Central Institute Of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization,1992)
2.Duration of illness to be more than or equal to two years.
3.Age between 18- 60 years of either sex
4.The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15
5.Scale for Assessment of Negative Symptoms (SANS) score more than 20
6.Right-handed
7.Educated upto class VIII or above
8.Patients giving written informed consent.
1.Presence of co-morbid neurological or other psychiatric disorder(s).
2.Patient with co morbid substance dependence, except nicotine and caffeine.
3.Having any metallic implants/parts in body
4.Subjects who have received ECT in past 6 months.
5.Colour blind
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in scores on negative and cognitive symptoms after application of HDtDCS.Timepoint: 1. At baseline <br/ ><br>2. At the end of 2 weeks <br/ ><br>3. At the end of 4 weeks
- Secondary Outcome Measures
Name Time Method Change in fMRI activation of Pre Frontal Cortex using cognitive task and change in resting state functional connectivity at baseline and after application of HDtDCS.Timepoint: 1. At baseline <br/ ><br>2. At the end of 2 weeks